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BDBM131744 US8829193, 18

SMILES: NC1CN(CCC1Cl)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cccc1F

InChI Key: InChIKey=IVDRVWFOHOJDBW-UHFFFAOYNA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 131744   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM131744
PNG
(US8829193, 18)
Show SMILES NC1CN(CCC1Cl)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
Show InChI InChI=1/C20H18ClF2N5OS/c21-11-5-7-28(9-14(11)24)17-4-6-25-8-15(17)26-19(29)16-10-30-20(27-16)18-12(22)2-1-3-13(18)23/h1-4,6,8,10-11,14H,5,7,9,24H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The activity of PIM1 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...


US Patent US8829193 (2014)


BindingDB Entry DOI: 10.7270/Q2SJ1J8V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM131744
PNG
(US8829193, 18)
Show SMILES NC1CN(CCC1Cl)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
Show InChI InChI=1/C20H18ClF2N5OS/c21-11-5-7-28(9-14(11)24)17-4-6-25-8-15(17)26-19(29)16-10-30-20(27-16)18-12(22)2-1-3-13(18)23/h1-4,6,8,10-11,14H,5,7,9,24H2,(H,26,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The activity of PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...


US Patent US8829193 (2014)


BindingDB Entry DOI: 10.7270/Q2SJ1J8V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM131744
PNG
(US8829193, 18)
Show SMILES NC1CN(CCC1Cl)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
Show InChI InChI=1/C20H18ClF2N5OS/c21-11-5-7-28(9-14(11)24)17-4-6-25-8-15(17)26-19(29)16-10-30-20(27-16)18-12(22)2-1-3-13(18)23/h1-4,6,8,10-11,14H,5,7,9,24H2,(H,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 54n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The activity of PIM2 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from kinase-catalyzed p...


US Patent US8829193 (2014)


BindingDB Entry DOI: 10.7270/Q2SJ1J8V
More data for this
Ligand-Target Pair