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BDBM131992 US8841455, 87

SMILES: CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(CC5)C(C)C)ccn34)c12

InChI Key: InChIKey=OAIHCGHCJBYTAV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131992   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM131992
PNG
(US8841455, 87)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(CC5)C(C)C)ccn34)c12
Show InChI InChI=1S/C32H41N9O2/c1-5-26-31-27(8-7-9-28(31)41(36-26)22-24-10-12-39(6-2)35-24)34-32(42)29-21-33-30-20-25(11-13-40(29)30)43-19-18-37-14-16-38(17-15-37)23(3)4/h7-13,20-21,23H,5-6,14-19,22H2,1-4H3,(H,34,42)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 168n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair