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BDBM132008 US8841455, 103

SMILES: CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCO)ccn34)c12

InChI Key: InChIKey=DPFMSWIHNGFWRO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132008   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM132008
PNG
(US8841455, 103)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCO)ccn34)c12
Show InChI InChI=1S/C26H26N6O3/c1-3-20-25-21(8-5-9-22(25)32(30-20)16-18-7-4-6-17(2)28-18)29-26(34)23-15-27-24-14-19(35-13-12-33)10-11-31(23)24/h4-11,14-15,33H,3,12-13,16H2,1-2H3,(H,29,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 192n/an/an/an/a7.322



Array BioPharma Inc

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair