BDBM13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::US20230348453, Compound A8::cid_3062316::med.21724, Compound Dasatinib

SMILES: Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl

InChI Key: InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Data: 13 KI  190 IC50  892 Kd  7 EC50

PDB links: 21 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1220 hits for monomerid = 13216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.5	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,E255K] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,M351T] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.700	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,F359V] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.300	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,H396P] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315I] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500,T315N] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [N822K] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit [V559D] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein-tyrosine kinase 6 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 6 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fgr (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Fyn (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase HCK (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lyn (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase mTOR (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	590	n/a	n/a	n/a	7.4	25
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.580	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.690	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Epidermal growth factor receptor [G719C] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0900	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Ephrin type-B receptor 3 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.90	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Ephrin type-B receptor 4 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.340	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.10E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.310	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	11	n/a	n/a	n/a	7.0	23
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase Src [251-533,T338M] (Chicken)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	7.0	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	11	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	495	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM13216 (N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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