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BDBM132535 US8841312, 284

SMILES: CCN(CC)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(O)c4n(C4CCCC4)c3n2)nc1

InChI Key: InChIKey=GZANMXDTOGPPAW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132535   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM132535
PNG
(US8841312, 284)
Show SMILES CCN(CC)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(O)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C28H36N8O/c1-3-34(4-2)19-12-15-35(16-13-19)21-9-10-24(30-17-21)32-28-31-18-23-22-11-14-29-27(37)25(22)36(26(23)33-28)20-7-5-6-8-20/h9-11,14,17-20H,3-8,12-13,15-16H2,1-2H3,(H,29,37)(H,30,31,32,33)
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UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/a7.437



Amgen Inc

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair