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BDBM132647 US8841312, 397

SMILES: O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n([C@H]2CCOC2)c2cnccc32)nn1

InChI Key: InChIKey=SBECQLBYVAZKCS-UONOGXRCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132647   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM132647
PNG
(US8841312, 397)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n([C@H]2CCOC2)c2cnccc32)nn1
Show InChI InChI=1S/C21H22N8O2/c30-14-4-7-28(11-14)19-2-1-18(26-27-19)24-21-23-9-16-15-3-6-22-10-17(15)29(20(16)25-21)13-5-8-31-12-13/h1-3,6,9-10,13-14,30H,4-5,7-8,11-12H2,(H,23,24,25,26)/t13-,14+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 340n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair