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BDBM13265 BMS-354825 2-Heteroarylamino-thiazole Analog 12j::CHEMBL365505::N-(2-Chloro-6-methylphenyl)-2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-[(6-methylpyridin-2-yl)amino]-1,3-thiazole-5-carboxamide

SMILES: Cc1cccc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1

InChI Key: InChIKey=XGXWRGOYVJXPFI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13265   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (Human))
BDBM13265
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12j |...)
Show SMILES Cc1cccc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1
Show InChI InChI=1S/C17H15ClN4OS/c1-10-5-3-7-12(18)15(10)22-16(23)13-9-19-17(24-13)21-14-8-4-6-11(2)20-14/h3-9H,1-2H3,(H,22,23)(H,19,20,21)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Bristol-Myers Squibb Co.



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair