BDBM13286 4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-hydroxy-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL93854::Sulfonamidopyrrolidinone 20a

SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2O)C(N)=N)C1=O

InChI Key InChIKey=WYPLWOJSDQFHPG-FQEVSTJZSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 13286   

TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  3nMAssay Description:Binding affinity against serine protease Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  3.16nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  206nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Rhone-Poulenc Rorer

LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  305nM ΔG°:  -8.79kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  305nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  1.07E+3nMAssay Description:Binding affinity against tissue plasminogen activator (t-Pa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  1.97E+3nMAssay Description:Binding affinity against activated protein C (APC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13286(4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfon...)
Affinity DataKi:  2.35E+3nMAssay Description:Binding affinity against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed