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BDBM133322 US8846719, 5

SMILES: Cc1onc(c1COc1ccc(cn1)C#N)-c1ccccc1

InChI Key: InChIKey=FYYZBZJEULZXAP-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 133322   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A))


(Homo sapiens (Human))
BDBM133322
PNG
(US8846719, 5)
Show SMILES Cc1onc(c1COc1ccc(cn1)C#N)-c1ccccc1
Show InChI InChI=1S/C17H13N3O2/c1-12-15(11-21-16-8-7-13(9-18)10-19-16)17(20-22-12)14-5-3-2-4-6-14/h2-8,10H,11H2,1H3
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Similars

US Patent
13.1 -9.99n/an/an/an/an/a7.54



Roche Palo Alto LLC

US Patent


Assay Description
Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...


US Patent US8846719 (2014)


BindingDB Entry DOI: 10.7270/Q2V986RV
More data for this
Ligand-Target Pair