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BDBM13363 (2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpropanamido]-3-methylbutanamido]-3-(4-hydroxy-2,5-dimethylphenyl)propanamido]-4-(methylsulfanyl)butanoic acid::CAAX Analogue 6::Compound VI

SMILES: CSCC[C@H](NC(=O)[C@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O

InChI Key: InChIKey=IZEXAYBNRDOHII-OYRVKSKDNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13363
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1/C24H38N4O6S2/c1-12(2)20(28-21(30)16(25)11-35)23(32)27-18(10-15-8-14(4)19(29)9-13(15)3)22(31)26-17(24(33)34)6-7-36-5/h8-9,12,16-18,20,29,35H,6-7,10-11,25H2,1-5H3,(H,26,31)(H,27,32)(H,28,30)(H,33,34)/t16-,17-,18-,20-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair