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BDBM133654 US8846719, 369

SMILES: NC(=O)c1ccc(nc1)C(OCc1conc1-c1ccc(F)cn1)C(F)(F)F

InChI Key: InChIKey=GSNVRZDAVSOMIL-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 133654   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A))


(Homo sapiens (Human))
BDBM133654
PNG
(US8846719, 369)
Show SMILES NC(=O)c1ccc(nc1)C(OCc1conc1-c1ccc(F)cn1)C(F)(F)F
Show InChI InChI=1/C17H12F4N4O3/c18-11-2-4-12(24-6-11)14-10(8-28-25-14)7-27-15(17(19,20)21)13-3-1-9(5-23-13)16(22)26/h1-6,8,15H,7H2,(H2,22,26)
PDB

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Similars

US Patent
9.30 -10.2n/an/an/an/an/a7.54



Roche Palo Alto LLC

US Patent


Assay Description
Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...


US Patent US8846719 (2014)


BindingDB Entry DOI: 10.7270/Q2V986RV
More data for this
Ligand-Target Pair