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BDBM133714 US8846699, 30

SMILES: CNCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C

InChI Key: InChIKey=XCGXIKJHGROCJB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 133714   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM133714
PNG
(US8846699, 30)
Show SMILES CNCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C20H19BrFN5O2/c1-3-19(28)26-17-9-13-16(10-18(17)29-7-6-23-2)24-11-25-20(13)27-15-5-4-12(21)8-14(15)22/h3-5,8-11,23H,1,6-7H2,2H3,(H,26,28)(H,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 96n/an/an/an/a7.425



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM133714
PNG
(US8846699, 30)
Show SMILES CNCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C20H19BrFN5O2/c1-3-19(28)26-17-9-13-16(10-18(17)29-7-6-23-2)24-11-25-20(13)27-15-5-4-12(21)8-14(15)22/h3-5,8-11,23H,1,6-7H2,2H3,(H,26,28)(H,24,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 513n/an/an/an/a7.425



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
VEGFR2 (KDR, Proquinase) enzyme assay (auto-phosphorylation assay) was carried out by using Tyrosine Kinase Assay Kit Green (Panvera). The entire ass...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair