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BDBM134278 US8846660, 96

SMILES: CCC[C@@H](NC(=O)N1CC2=NOCC(=O)N2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1

InChI Key: InChIKey=XGZXMBNUKNJTHA-FBLFFUNLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134278   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM134278
PNG
(US8846660, 96)
Show SMILES CCC[C@@H](NC(=O)N1CC2=NOCC(=O)N2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C27H30ClN5O7/c1-3-4-21(15-5-7-19(26(36)37)20(29)11-15)30-27(38)33-13-23-31-40-14-24(34)32(23)12-17(25(33)35)9-16-10-18(28)6-8-22(16)39-2/h5-8,10-11,17,21H,3-4,9,12-14,29H2,1-2H3,(H,30,38)(H,36,37)/t17?,21-/m1/s1
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MMDB

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Similars

US Patent
n/an/a 7n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair