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BDBM134700 US8846698, 163

SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3c(C)[nH]nc3-c3ccccc3)c2)c2cncnc12

InChI Key: InChIKey=XRPJYJHVRLPBKJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134700   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134700
PNG
(US8846698, 163)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3c(C)[nH]nc3-c3ccccc3)c2)c2cncnc12
Show InChI InChI=1S/C27H25N7O2/c1-16(2)34-14-23(22-13-29-15-30-27(22)34)26(36)19-9-20(12-28-11-19)31-24(35)10-21-17(3)32-33-25(21)18-7-5-4-6-8-18/h4-9,11-16H,10H2,1-3H3,(H,31,35)(H,32,33)
PDB
MMDB

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Similars

US Patent
n/an/a 1.84E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair