BDBM134700 US8846698, 163

SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3c(C)[nH]nc3-c3ccccc3)c2)c2cncnc12

InChI Key: InChIKey=XRPJYJHVRLPBKJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134700   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM134700 (US8846698, 163) Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3c(C)[nH]nc3-c3ccccc3)c2)c2cncnc12 Show InChI InChI=1S/C27H25N7O2/c1-16(2)34-14-23(22-13-29-15-30-27(22)34)26(36)19-9-20(12-28-11-19)31-24(35)10-21-17(3)32-33-25(21)18-7-5-4-6-8-18/h4-9,11-16H,10H2,1-3H3,(H,31,35)(H,32,33)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
					More data for this Ligand-Target Pair