BindingDB logo
myBDB logout

BDBM134851 US8846698, 325

SMILES: Cn1cc(C(=O)c2cncc(NC(=O)COc3ccccc3OC(F)(F)F)c2)c2cncnc12

InChI Key: InChIKey=ZVPVTXINBQIRTL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134851   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134851
PNG
(US8846698, 325)
Show SMILES Cn1cc(C(=O)c2cncc(NC(=O)COc3ccccc3OC(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C22H16F3N5O4/c1-30-10-16(15-9-27-12-28-21(15)30)20(32)13-6-14(8-26-7-13)29-19(31)11-33-17-4-2-3-5-18(17)34-22(23,24)25/h2-10,12H,11H2,1H3,(H,29,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 111n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair