BDBM135816 US10085990, Example 54::US10568888, Example 54::US8853226, 54::US9393245, 54::US9833457, 54
SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
InChI Key InChIKey=NMCBQDCTQPGXHQ-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 135816
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 78nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 338nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics
US Patent
Vtv Therapeutics
US Patent
Affinity DataIC50: 78nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...More data for this Ligand-Target Pair
TargetIsoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)(Homo sapiens (Human))
Vtv Therapeutics
US Patent
Vtv Therapeutics
US Patent
Affinity DataIC50: 338nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 338nMAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 78nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 338nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics
US Patent
Vtv Therapeutics
US Patent
Affinity DataIC50: 78nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 338nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
High Point Pharmaceuticals
US Patent
High Point Pharmaceuticals
US Patent
Affinity DataIC50: 78nMAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
TargetLipopolysaccharide-induced tumor necrosis factor-alpha factor(Homo sapiens (Human))
Vtv Therapeutics
US Patent
Vtv Therapeutics
US Patent
Affinity DataIC50: 6nMAssay Description:Samples were tested for TNF as per the manufacturer's instructions (TNF ELISA; R&D Systems, Cat #DY210). The samples were serially diluted with P...More data for this Ligand-Target Pair