BDBM13590 (2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-2-fluoro-3-[(3R)-oxolan-3-yloxy]phenyl}acetic acid::(R)-(4-Carbamimidoyl-phenylamino)-{3-ethoxy-2-fluoro-5-[(R)-(tetra-hydro-furan-3-yl)-oxy]-phenyl}-acetic acid::phenylglycine derivative 5

SMILES CCOc1cc(O[C@@H]2CCOC2)c(F)c(c1)[C@@H](Nc1ccc(cc1)C(N)=N)C(O)=O

InChI Key InChIKey=PGYOHIAQCFZQDK-AUUYWEPGSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13590   

TargetCoagulation factor VII(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM13590((2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-...)
Affinity DataKi:  81nM ΔG°:  -9.57kcal/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM13590((2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-...)
Affinity DataKi:  1.90E+3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
F. Hoffmann-La Roche

LigandPNGBDBM13590((2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-...)
Affinity DataKi:  3.20E+3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM13590((2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-...)
Affinity DataKi:  4.50E+3nM ΔG°:  -7.22kcal/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed