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BDBM136177 US8853193, 16-4

SMILES: CC(CCN)Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12

InChI Key: InChIKey=HTVNCUQKQNWSAE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136177   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136177
PNG
(US8853193, 16-4)
Show SMILES CC(CCN)Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C17H20N6O2S/c1-9(5-6-18)25-16-11(4-3-7-20-16)23-15-12-10(2)13(14(19)24)26-17(12)22-8-21-15/h3-4,7-9H,5-6,18H2,1-2H3,(H2,19,24)(H,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair