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BDBM137243 US8871790, 322

SMILES: Cc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC1)C(=O)N1CCC(F)(CC1)c1ccc(cn1)C#N

InChI Key: InChIKey=WOXKITSARLKFGT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 137243   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty acid synthase


(Homo sapiens (Human))
BDBM137243
PNG
(US8871790, 322)
Show SMILES Cc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC1)C(=O)N1CCC(F)(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C28H27FN6O2/c1-19-3-5-21(15-23(19)33-26(36)22-6-8-25(32-18-22)34-11-2-12-34)27(37)35-13-9-28(29,10-14-35)24-7-4-20(16-30)17-31-24/h3-8,15,17-18H,2,9-14H2,1H3,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 180n/an/an/an/an/an/a



3-V Biosciences, Inc.

US Patent


Assay Description
The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...


US Patent US8871790 (2014)


BindingDB Entry DOI: 10.7270/Q2PG1QD3
More data for this
Ligand-Target Pair