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BDBM137248 US8871790, 327

SMILES: Cc1ccc(cc1NC(=O)NCC1CCNCC1)C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N

InChI Key: InChIKey=KXYHQEBHEZDGRU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 137248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty acid synthase


(Homo sapiens (Human))
BDBM137248
PNG
(US8871790, 327)
Show SMILES Cc1ccc(cc1NC(=O)NCC1CCNCC1)C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H32FN5O2/c1-19-2-5-22(16-24(19)32-26(35)31-18-21-8-12-30-13-9-21)25(34)33-14-10-27(28,11-15-33)23-6-3-20(17-29)4-7-23/h2-7,16,21,30H,8-15,18H2,1H3,(H2,31,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 610n/an/an/an/an/an/a



3-V Biosciences, Inc.

US Patent


Assay Description
The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...


US Patent US8871790 (2014)


BindingDB Entry DOI: 10.7270/Q2PG1QD3
More data for this
Ligand-Target Pair