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BDBM13740 2-(benzylamino)-5-isopropyl-5-methylthiazol-4(5H)-one::2-(benzylamino)-5-methyl-5-(propan-2-yl)-4,5-dihydro-1,3-thiazol-4-one::2-Benzylamine analog 2

SMILES: CC(C)C1(C)SC(NCc2ccccc2)=NC1=O

InChI Key: InChIKey=IUURRDZAZOQTCE-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13740   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM13740
PNG
(2-(benzylamino)-5-isopropyl-5-methylthiazol-4(5H)-...)
Show SMILES CC(C)C1(C)SC(NCc2ccccc2)=NC1=O
Show InChI InChI=1/C14H18N2OS/c1-10(2)14(3)12(17)16-13(18-14)15-9-11-7-5-4-6-8-11/h4-8,10H,9H2,1-3H3,(H,15,16,17)
PDB
MMDB

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Patents


Similars

Article
PubMed
65 -9.70n/an/an/an/an/a7.222



Amgen Inc



Assay Description
Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...


J Med Chem 50: 429-32 (2007)


Article DOI: 10.1021/jm061214f
BindingDB Entry DOI: 10.7270/Q20Z71JH
More data for this
Ligand-Target Pair