BDBM138044 US8871934, 637

SMILES: Cn1cc(cn1)-c1cc2c(-c3ccccc3C2(O)C(F)(F)F)c(CC(N)=O)c1

InChI Key: InChIKey=FRXAARMCPIPDFK-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 138044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (Homo sapiens (Human))	BDBM138044 (US8871934, 637) Show SMILES Cn1cc(cn1)-c1cc2c(-c3ccccc3C2(O)C(F)(F)F)c(CC(N)=O)c1 Show InChI InChI=1S/C20H16F3N3O2/c1-26-10-13(9-25-26)11-6-12(8-17(24)27)18-14-4-2-3-5-15(14)19(28,16(18)7-11)20(21,22)23/h2-7,9-10,28H,8H2,1H3,(H2,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	8.0	30
Japan Tobacco Inc US Patent					Assay Description The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...				US Patent US8871934 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZQT
					More data for this Ligand-Target Pair