BDBM139370 ACP-103::Nuplazid::Pimavanserin::Pimavanserin hydrochloride::Pimavanserin tartrate::US20230348421, Compound Pimavanserin::WO2023288027, Cmpd PIMA::bis(1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate

SMILES: CC(C)COc1ccc(cc1)CNC(=O)N(Cc2ccc(cc2)F)C3CCN(CC3)C

InChI Key: InChIKey=RKEWSXXUOLRFBX-UHFFFAOYSA-N

Data: 8 KI  17 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 139370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27.3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		0.5	-11.8	n/a	n/a	n/a	n/a	n/a	n/a	4
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5-hydroxytryptamine receptor 2A (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		0.860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		1.60	-11.1	n/a	n/a	n/a	n/a	n/a	n/a	4
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BDBP50000595 (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		2.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2B (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		436	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Human)	BDBM139370 (ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...) Show SMILES Show InChI	GoogleScholar	UniChem		3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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