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BDBM139372 US8889671, 1

SMILES: C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2CCOC2=O)C(=O)NC(=O)NC1=O

InChI Key: InChIKey=CDAHTPNJGHKIRM-KFEVFCGQNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139372   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139372
PNG
(US8889671, 1)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2CCOC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C21H20FN5O7/c1-8-7-27-13-10(5-11-14(12(13)22)34-25-16(11)26-3-4-32-20(26)31)6-21(15(27)9(2)33-8)17(28)23-19(30)24-18(21)29/h5,8-9,15H,3-4,6-7H2,1-2H3,(H2,23,24,28,29,30)/t8-,9+,15-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30E+3n/an/an/an/a7.5n/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)


BindingDB Entry DOI: 10.7270/Q22J69JX
More data for this
Ligand-Target Pair