BindingDB logo
myBDB logout

BDBM139602 US8889870, 148::US9388176, 148::US9820989, 148

SMILES: Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1

InChI Key: InChIKey=LYMPBMGKFUQEMN-UHFFFAOYSA-N

Data: 2 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 139602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
27n/an/an/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9820989 (2017)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
273n/an/an/an/an/an/an/an/a



Allergan Inc

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9820989 (2017)


Article DOI: 10.1021/jm051187d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 273n/an/an/an/a7.430



Allergan Inc

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


US Patent US9388176 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60DZ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 273n/an/an/an/a7.4n/a



Allergan Inc

US Patent


Assay Description
Biochemical PDGFR.beta. kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 .mu.g of poly-Glu-Tyr (4:1) in 1...


US Patent US8889870 (2014)


BindingDB Entry DOI: 10.7270/Q25B0158
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/a7.4n/a



Allergan Inc

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...


US Patent US8889870 (2014)


BindingDB Entry DOI: 10.7270/Q25B0158
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/a7.430



Allergan Inc

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


US Patent US9388176 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60DZ
More data for this
Ligand-Target Pair