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BDBM139739 US8895549, 29

SMILES: COc1c(OC[C@H](O)CN(C)C)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12

InChI Key: InChIKey=BLIHTECITGWBCE-UGPWUYPHNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139739   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM139739
PNG
(US8895549, 29)
Show SMILES COc1c(OC[C@H](O)CN(C)C)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12
Show InChI InChI=1/C21H26N8O4/c1-28(2)10-13(30)11-33-15-5-4-14-16(17(15)32-3)26-21(29-7-6-23-18(14)29)27-19(31)12-8-24-20(22)25-9-12/h4-5,8-9,13,30H,6-7,10-11H2,1-3H3,(H2,22,24,25)(H,26,27,31)/t13-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.75n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...


US Patent US8895549 (2014)


BindingDB Entry DOI: 10.7270/Q2NC5ZWF
More data for this
Ligand-Target Pair