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BDBM139912 US8895745, 359

SMILES: CN(N)\N=C(/N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1

InChI Key: InChIKey=NZJRYBFNAVWOTQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139912   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139912
PNG
(US8895745, 359)
Show SMILES CN(N)\N=C(/N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N8O/c1-28(23)27-16(22)12-5-6-29-14(9-24-15(29)8-12)11-3-2-4-13(7-11)26-17(30)25-10-18(19,20)21/h2-9H,10,23H2,1H3,(H2,22,27)(H2,25,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.4n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair