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BDBM140927 US8912224, 365

SMILES: CCn1nccc1CNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2cccc(F)c2OC)s1

InChI Key: InChIKey=KUACHYYHKNOCTF-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140927   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/calcium exchanger 1(NCX1)


(Homo sapiens (Human))
BDBM140927
PNG
(US8912224, 365)
Show SMILES CCn1nccc1CNC(=O)c1cnc(Oc2ccc3OC(CCc3c2)c2cccc(F)c2OC)s1
Show InChI InChI=1/C26H25FN4O4S/c1-3-31-17(11-12-30-31)14-28-25(32)23-15-29-26(36-23)34-18-8-10-21-16(13-18)7-9-22(35-21)19-5-4-6-20(27)24(19)33-2/h4-6,8,10-13,15,22H,3,7,9,14H2,1-2H3,(H,28,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 550n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loade...


US Patent US8912224 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M52
More data for this
Ligand-Target Pair