BindingDB logo
myBDB logout

BDBM141326 US8916577, 67

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3CCCc4c(nn(C)c4-c3n2)C(N)=O)cc1

InChI Key: InChIKey=ACMMEMWMPLSEFY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 141326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein kinase TTK


(Homo sapiens (Human))
BDBM141326
PNG
(US8916577, 67)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCCc4c(nn(C)c4-c3n2)C(N)=O)cc1
Show InChI InChI=1S/C23H28N8O/c1-29-10-12-31(13-11-29)17-8-6-16(7-9-17)26-23-25-14-15-4-3-5-18-20(22(24)32)28-30(2)21(18)19(15)27-23/h6-9,14H,3-5,10-13H2,1-2H3,(H2,24,32)(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.20E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences srl

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8916577 (2014)


BindingDB Entry DOI: 10.7270/Q25719RJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM141326
PNG
(US8916577, 67)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCCc4c(nn(C)c4-c3n2)C(N)=O)cc1
Show InChI InChI=1S/C23H28N8O/c1-29-10-12-31(13-11-29)17-8-6-16(7-9-17)26-23-25-14-15-4-3-5-18-20(22(24)32)28-30(2)21(18)19(15)27-23/h6-9,14H,3-5,10-13H2,1-2H3,(H2,24,32)(H,25,26,27)
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.60E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences srl

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8916577 (2014)


BindingDB Entry DOI: 10.7270/Q25719RJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM141326
PNG
(US8916577, 67)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCCc4c(nn(C)c4-c3n2)C(N)=O)cc1
Show InChI InChI=1S/C23H28N8O/c1-29-10-12-31(13-11-29)17-8-6-16(7-9-17)26-23-25-14-15-4-3-5-18-20(22(24)32)28-30(2)21(18)19(15)27-23/h6-9,14H,3-5,10-13H2,1-2H3,(H2,24,32)(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.45E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences srl

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8916577 (2014)


BindingDB Entry DOI: 10.7270/Q25719RJ
More data for this
Ligand-Target Pair