BDBM141440 US10668051, Compound Example 107::US8921364, 107

SMILES Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F

InChI Key InChIKey=WVXWEWXVLIUSCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141440   

TargetCalcium release-activated calcium channel protein 1(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141440(US10668051, Compound Example 107 | US8921364, 107)
Affinity DataIC50:  70.3nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEF-hand calcium-binding domain-containing protein 4B(Homo sapiens (Human))
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141440(US10668051, Compound Example 107 | US8921364, 107)
Affinity DataIC50:  70.3nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
In DepthDetails US Patent