BindingDB logo
myBDB logout

BDBM141649 US8921389, 106::US9695170 106

SMILES: NS(=O)(=O)CCNC(=O)c1nc(C#N)c2ccc(=O)n(Cc3ccccc3)c2c1O

InChI Key: InChIKey=NMIVQXVCSFGLTO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141649   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIF-PH2


(Homo sapiens (Human))
BDBM141649
PNG
(US8921389, 106 | US9695170 106)
Show SMILES NS(=O)(=O)CCNC(=O)c1nc(C#N)c2ccc(=O)n(Cc3ccccc3)c2c1O
Show InChI InChI=1S/C19H17N5O5S/c20-10-14-13-6-7-15(25)24(11-12-4-2-1-3-5-12)17(13)18(26)16(23-14)19(27)22-8-9-30(21,28)29/h1-7,26H,8-9,11H2,(H,22,27)(H2,21,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>2.00E+5n/an/an/an/a7.4n/a



FibroGen Inc

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


US Patent US9695170 (2017)


BindingDB Entry DOI: 10.7270/Q2P55KN0
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM141649
PNG
(US8921389, 106 | US9695170 106)
Show SMILES NS(=O)(=O)CCNC(=O)c1nc(C#N)c2ccc(=O)n(Cc3ccccc3)c2c1O
Show InChI InChI=1S/C19H17N5O5S/c20-10-14-13-6-7-15(25)24(11-12-4-2-1-3-5-12)17(13)18(26)16(23-14)19(27)22-8-9-30(21,28)29/h1-7,26H,8-9,11H2,(H,22,27)(H2,21,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>2.00E+5n/an/an/an/a7.4n/a



FibroGen Inc

US Patent


Assay Description
Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources,...


US Patent US8921389 (2014)


BindingDB Entry DOI: 10.7270/Q20G3HV0
More data for this
Ligand-Target Pair