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BDBM141720 US8921389, 178::US9695170 178

SMILES: Cc1ncccc1-c1nc(C(=O)NCCC(O)=O)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12

InChI Key: InChIKey=KNRQAKCYUKDZQW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141720   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIF-PH2


(Homo sapiens (Human))
BDBM141720
PNG
(US8921389, 178 | US9695170 178)
Show SMILES Cc1ncccc1-c1nc(C(=O)NCCC(O)=O)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12
Show InChI InChI=1S/C31H26N4O5/c1-19-22(13-8-15-32-19)26-28-24(29(38)27(34-26)30(39)33-16-14-25(36)37)17-23(21-11-6-3-7-12-21)31(40)35(28)18-20-9-4-2-5-10-20/h2-13,15,17,38H,14,16,18H2,1H3,(H,33,39)(H,36,37)
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UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.99E+5n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


US Patent US9695170 (2017)


BindingDB Entry DOI: 10.7270/Q2P55KN0
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM141720
PNG
(US8921389, 178 | US9695170 178)
Show SMILES Cc1ncccc1-c1nc(C(=O)NCCC(O)=O)c(O)c2cc(-c3ccccc3)c(=O)n(Cc3ccccc3)c12
Show InChI InChI=1S/C31H26N4O5/c1-19-22(13-8-15-32-19)26-28-24(29(38)27(34-26)30(39)33-16-14-25(36)37)17-23(21-11-6-3-7-12-21)31(40)35(28)18-20-9-4-2-5-10-20/h2-13,15,17,38H,14,16,18H2,1H3,(H,33,39)(H,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.99E+5n/an/an/an/a7.4n/a



Fibrogen, Inc.

US Patent


Assay Description
Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources,...


US Patent US8921389 (2014)


BindingDB Entry DOI: 10.7270/Q20G3HV0
More data for this
Ligand-Target Pair