BDBM142088 US11096924, DASH-inhibitors 2243::US11559537, Compound 2243::US8933056, Ala-boroPro Thioxamide

SMILES C[C@H](N)C(=S)N1CCC[C@H]1B(O)O

InChI Key InChIKey=ZEMFLZQUUHJMGT-WDSKDSINSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 142088   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  0.350nMpH: 2.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  135nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  4.90E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  2.80E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  200nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  200nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  1.30E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHomeobox protein PKNOX1(Human)
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  4.40E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  1.35E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  4.90nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  2.80nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  0.200nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  0.200nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  130nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  440nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM142088(US11096924, DASH-inhibitors 2243 | US11559537, Com...)
Affinity DataIC50:  2.00E+4nMpH: 8.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair
In DepthDetails US Patent