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BDBM142388 US8933221, 29

SMILES: NC1=N[C@]2(CO[C@@H](CO)C[C@H]2CS1)c1ccccc1F

InChI Key: InChIKey=QOTXVNVFFXKYIK-TZYNDVBBNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 142388   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM142388
PNG
(US8933221, 29)
Show SMILES NC1=N[C@]2(CO[C@@H](CO)C[C@H]2CS1)c1ccccc1F
Show InChI InChI=1/C14H17FN2O2S/c15-12-4-2-1-3-11(12)14-8-19-10(6-18)5-9(14)7-20-13(16)17-14/h1-4,9-10,18H,5-8H2,(H2,16,17)/t9-,10+,14-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.41E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...


US Patent US8933221 (2015)


BindingDB Entry DOI: 10.7270/Q2513WXH
More data for this
Ligand-Target Pair