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BDBM142518 US8933224, 111

SMILES: Cc1nc(-c2ccccc2F)c2c(ncnn12)N1CCc2nc(C)ncc2C1

InChI Key: InChIKey=ZAXBZHWQTXDADR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 142518   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM142518
PNG
(US8933224, 111)
Show SMILES Cc1nc(-c2ccccc2F)c2c(ncnn12)N1CCc2nc(C)ncc2C1
Show InChI InChI=1S/C20H18FN7/c1-12-22-9-14-10-27(8-7-17(14)25-12)20-19-18(15-5-3-4-6-16(15)21)26-13(2)28(19)24-11-23-20/h3-6,9,11H,7-8,10H2,1-2H3
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18.6n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM142518
PNG
(US8933224, 111)
Show SMILES Cc1nc(-c2ccccc2F)c2c(ncnn12)N1CCc2nc(C)ncc2C1
Show InChI InChI=1S/C20H18FN7/c1-12-22-9-14-10-27(8-7-17(14)25-12)20-19-18(15-5-3-4-6-16(15)21)26-13(2)28(19)24-11-23-20/h3-6,9,11H,7-8,10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.85n/an/an/an/a7.5n/a



Pfizer Inc

US Patent


Assay Description
The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...


US Patent US8933224 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C35
More data for this
Ligand-Target Pair