BDBM14361 (R,S)-Rolipram::4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one::4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one::Adeo::CHEMBL63::Rolipram

SMILES: COc1ccc(cc1OC2CCCC2)[C@H]3CC(=O)NC3

InChI Key: InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

Data: 29 KI  246 IC50  3 EC50

PDB links: 9 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 278 hits for monomerid = 14361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphodiesterase (Trypanosoma cruzi)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional epoxide hydrolase 2 (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bovine)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.46E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B (Bovine)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tumor necrosis factor (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tumor necrosis factor (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Mouse)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rat)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rat)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rat)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14361 (Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair