BDBM14374 (2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{2-[(3,5-dimethoxyphenyl)methoxy]propan-2-yl}-3H-purin-6-amine::3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,5-dimethoxy-benzyloxy)-1-methyl-ethyl]-3Hpurin-6-ylamine Fumarate::V11294 Analogue 5j

SMILES COc1cc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc(OC)c1

InChI Key InChIKey=WKIZWUJJDQILGH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14374   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14374((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...)
Affinity DataKi:  7.90nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14374((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...)
Affinity DataKi:  9nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14374((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...)
Affinity DataKi:  21.9nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14374((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...)
Affinity DataKi:  225nM ΔG°:  -8.97kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14374((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...)
Affinity DataKi:  340nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed