BDBM14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::US11897890, Compound sildenafil::US12139461, Compound sildenafil::Viagra

SMILES: CCCc1c2c(n(n1)C)C(=O)NC(=N2)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC4)C

InChI Key: InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N

Data: 12 KI  185 IC50  3 EC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 200 hits for monomerid = 14390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.4	30
TBA									Citation and Details
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Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (Dog)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	7.4	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [535-860] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.8	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	7.8	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875] (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	188	n/a	n/a	n/a	n/a	7.8	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphodiesterase (Trypanosoma cruzi)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (SARS-CoV)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Rat)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	819	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bovine)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM14390 (SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair