BDBM14418 3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one::benzimidazolone analog 2b

SMILES Cn1cncc1C(O)(c1ccc(I)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1

InChI Key InChIKey=NJYJMHAGSUDRMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14418   

LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50:  1.20E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed