BDBM144202 US8969335, A26

SMILES OC[C@H]1C[C@@H]1Cn1cc(Nc2cc(ccn2)-c2ccc(OC3CCOCC3)c(c2)C#N)cn1

InChI Key InChIKey=HNDZOIQVTDQHDZ-NHCUHLMSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144202   

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM144202(US8969335, A26)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM144202(US8969335, A26)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...More data for this Ligand-Target Pair
In DepthDetails US Patent