BDBM14421 4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl](1-methyl-1H-imidazol-5-yl)methyl}benzonitrile::benzimidazolone analog 2e

SMILES COc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N

InChI Key InChIKey=AZZIYZHDQXWUCK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14421   

LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
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LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50:  5.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed