BDBM144315 Gilteritinib::US11512074, Example T-9::US8969336, 547::US8969336, 577

SMILES: CCc1c(nc(c(n1)C(=O)N)Nc2ccc(c(c2)OC)N3CCC(CC3)N4CCN(CC4)C)NC5CCOCC5

InChI Key: InChIKey=GYQYAJJFPNQOOW-UHFFFAOYSA-N

Data: 5 KI  44 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 144315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leukocyte tyrosine kinase receptor (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.199	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.187	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.01	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.87	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.33	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.24	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM144315 (US8969336, 577 | US8969336, 547 | Gilteritinib | U...) Show SMILES Show InChI	GoogleScholar	UniChem		10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair