BDBM14433 4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}piperidin-1-yl)-2-oxoethyl]piperidine-1-carboxamide::4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide::Lonafarnib::SCH-66336::Sarasar::racemic mixture

SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)C2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1

InChI Key InChIKey=DHMTURDWPRKSOA-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14433   

LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair