BDBM14434 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one::6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one::R-115777::R-115777 | Zarnestra::Racemic mixture::Tipifarnib::Zarnestra

SMILES: Cn1cncc1[C@@](c2ccc(cc2)Cl)(c3ccc4c(c3)C(=CC(=O)N4C)c5cccc(c5)Cl)N

InChI Key: InChIKey=PLHJCIYEEKOWNM-UHFFFAOYSA-N

Data: 7 IC50  1 Other

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14434   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-dependent RNA helicase RhlE (Vibrio fischeri (strain ATCC 700601 / ES114))	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.860	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14434 (Racemic mixture | R-115777 | 6-[amino(4-chlorophen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair