BDBM14459 (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidin-yl]-2-oxo-ethyl]-1-piperidinecarboxamide::4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide::CHEMBL298734::Lonafarnib::SCH 66336::Sarasar

SMILES: NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1

InChI Key: InChIKey=DHMTURDWPRKSOA-UHFFFAOYSA-N

Data: 19 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 14459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
GTPase KRas (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mouse)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
ATP-dependent RNA helicase RhlE (Vibrio fischeri (strain ATCC 700601 / ES114))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Rat)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Rat)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Human)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair