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BDBM144648 US8952037, 15

SMILES: CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1C[C@@H](C1)Nc1ccc2ccccc2n1

InChI Key: InChIKey=UUKCBNBPKAEKBA-MXVIHJGJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144648   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM144648
PNG
(US8952037, 15)
Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1C[C@@H](C1)Nc1ccc2ccccc2n1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-12-8-18(9-13-29)23-24(26-11-10-25-23)31-20-14-19(15-20)27-22-7-6-17-4-2-3-5-21(17)28-22/h2-7,10-11,18-20H,8-9,12-15H2,1H3,(H,27,28)/t19-,20-
PDB
MMDB

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PC cid
PC sid
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Similars

US Patent
n/an/a 15.8n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...


US Patent US8952037 (2015)


BindingDB Entry DOI: 10.7270/Q23X85CW
More data for this
Ligand-Target Pair