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BDBM144724 US8952037, 108

SMILES: FC(F)(F)c1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1

InChI Key: InChIKey=MUVPXYPHRKIAAD-WKILWMFINA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144724   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM144724
PNG
(US8952037, 108)
Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1
Show InChI InChI=1/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16-
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 106n/an/an/an/an/a25



Amgen Inc

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...


US Patent US8952037 (2015)


BindingDB Entry DOI: 10.7270/Q23X85CW
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM144724
PNG
(US8952037, 108)
Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1
Show InChI InChI=1/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 436n/an/an/an/an/a25



Amgen Inc

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...


US Patent US8952037 (2015)


BindingDB Entry DOI: 10.7270/Q23X85CW
More data for this
Ligand-Target Pair