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BDBM145888 US8957064, 25.0

SMILES: Cc1cnc2nc(-c3ccc(CN4CC(C4)c4n[nH]c(n4)-c4cccc(C)n4)cc3)c(cn12)-c1ccccc1

InChI Key: InChIKey=RYHINOVPVSNHAE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145888   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM145888
PNG
(US8957064, 25.0)
Show SMILES Cc1cnc2nc(-c3ccc(CN4CC(C4)c4n[nH]c(n4)-c4cccc(C)n4)cc3)c(cn12)-c1ccccc1
Show InChI InChI=1S/C31H28N8/c1-20-7-6-10-27(33-20)30-35-29(36-37-30)25-17-38(18-25)16-22-11-13-24(14-12-22)28-26(23-8-4-3-5-9-23)19-39-21(2)15-32-31(39)34-28/h3-15,19,25H,16-18H2,1-2H3,(H,35,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...


US Patent US8957064 (2015)


BindingDB Entry DOI: 10.7270/Q2Z60MRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM145888
PNG
(US8957064, 25.0)
Show SMILES Cc1cnc2nc(-c3ccc(CN4CC(C4)c4n[nH]c(n4)-c4cccc(C)n4)cc3)c(cn12)-c1ccccc1
Show InChI InChI=1S/C31H28N8/c1-20-7-6-10-27(33-20)30-35-29(36-37-30)25-17-38(18-25)16-22-11-13-24(14-12-22)28-26(23-8-4-3-5-9-23)19-39-21(2)15-32-31(39)34-28/h3-15,19,25H,16-18H2,1-2H3,(H,35,36,37)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...


US Patent US8957064 (2015)


BindingDB Entry DOI: 10.7270/Q2Z60MRP
More data for this
Ligand-Target Pair