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BDBM146058 US8957068, 93

SMILES: CC(C)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccccc2)n1

InChI Key: InChIKey=YURLMTCLTRJEOO-GOEBONIOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 146058   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isocitrate dehydrogenase [NADP] cytoplasmic


(Homo sapiens (Human))
BDBM146058
PNG
(US8957068, 93)
Show SMILES CC(C)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccccc2)n1
Show InChI InChI=1S/C19H24N4O2/c1-12(2)16-11-25-19(24)23(16)17-10-13(3)20-18(22-17)21-14(4)15-8-6-5-7-9-15/h5-10,12,14,16H,11H2,1-4H3,(H,20,21,22)/t14-,16+/m0/s1
PDB

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Similars

US Patent
n/an/a 655n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...


US Patent US8957068 (2015)


BindingDB Entry DOI: 10.7270/Q2TD9W28
More data for this
Ligand-Target Pair