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BDBM146103 US8957068, 138

SMILES: CC(C)C[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)C(C)C

InChI Key: InChIKey=KEAQVHJQQITVLP-QWAQRTLVNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 146103   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isocitrate dehydrogenase [NADP] cytoplasmic


(Homo sapiens (Human))
BDBM146103
PNG
(US8957068, 138)
Show SMILES CC(C)C[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)C(C)C
Show InChI InChI=1/C16H26N4O2/c1-10(2)8-12(5)18-15-17-7-6-14(19-15)20-13(11(3)4)9-22-16(20)21/h6-7,10-13H,8-9H2,1-5H3,(H,17,18,19)/t12-,13+/s2
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.06E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...


US Patent US8957068 (2015)


BindingDB Entry DOI: 10.7270/Q2TD9W28
More data for this
Ligand-Target Pair